Apoptotic mitochondria blow a fuse

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Apoptotic mitochondria blow a fuse

ranscription factor JunB negatively regulates proliferation in several cell types. But Kenner et al. (page 613) show that JunB, which acts as one-half of an AP-1 dimer, is a positive regulator of both osteo-blast and osteoclast proliferation and differentiation. In the process they have produced a new animal model for studying osteoporosis. As JunB is essential for placenta formation, the autho...

متن کامل

Fussy mitochondria fuse in response to stress

When cells become committed to apoptosis, they shatter their mitochondrial networks through the actions of the mitochondrial fission protein DRP1. Massive fragmentation of mitochondria facilitates simultaneous release of cytochrome c from all mitochondria within a cell, thus promoting further progression along the apoptotic pathway. In this issue, Tondera et al (2009) describe a new process wit...

متن کامل

Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles

Mitochondria, play an important role in a variety of processes including energy production, apoptosis, autophagy and inflammation. Caspases, are proteases that play an essential role in mediating apoptotic process of programmed cell death. An association between mitochondria and caspases is very well defined during apoptosis. Besides apoptosis, emerging data is strongly suggesting a direct asso...

متن کامل

Mitochondria as the target of the pro-apoptotic protein Bax.

During apoptosis, engagement of the mitochondrial pathway involves the permeabilization of the outer mitochondrial membrane (OMM), which leads to the release of cytochrome c and other apoptogenic proteins such as Smac/DIABLO, AIF, EndoG, Omi/HtraA2 and DDP/TIMM8a. OMM permeabilization depends on activation, translocation and oligomerization of multidomain Bcl-2 family proteins such as Bax or Ba...

متن کامل

Maslinic acid activates mitochondria-dependent apoptotic pathway in cardiac carcinoma.

PURPOSE Cardiac carcinoma is the most common subtype of gastric cancer and its incidence has increased in recent years. The current chemotherapeutic drugs exhibit limited effectiveness and significant side effects in patients. Maslinic acid (MA) exerts an anti-tumor activity on a wide range of cancers and has no significant side effect; however, the anti-tumor effect of MA on cardiac carcinoma ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2004

ISSN: 1540-8140,0021-9525

DOI: 10.1083/jcb1644iti5